Hiroshi Kimura, MD, PhD. BIBLIOGRAPHY

Original Papers

1. Honda Y, Hayashi F, Yoshida A, Ohyabu Y, Nishibayashi Y, Kimura H. Overall "gain" of the respiratory control system in normoxic humans awake and asleep. J. Appl. Physiol. 55:1530-1535, 1983.

2. Kimura H, Hayashi F, Yoshida A, Watanabe S, Hashizume I, Honda Y. Augmentation of CO2 drives by chlormadinone acetate, a synthetic progesterone. J. Appl. Physiol. 56:1627-1632, 1984.

3. Kimura H, Tatsumi K, Kuriyama T, Sugita T, Watanabe S, Nishibayashi Y, Honda Y. Effects of chlormadinone acetate, a synthetic progesterone, on restoring impaired load compensation in chronic obstructive pulmonary disease. Tohoku J. Exp. Med. 149:119-132, 1986.

4. Masuyama S, Kimura H, Sugita T, Kuriyama T, Tatsumi K, Kunitomo F, Okita S, Tojima H, Yuguchi Y, Watanabe S, Honda Y. Control of ventilation in extreme-altitude climbers. J. Appl. Physiol. 61:500-506, 1986.

5. Tatsumi K, Kimura H, Kunitomo F, Okita S, Tojima H, Yuguchi Y, Kuriyama T, Watanabe S, Honda Y. Effects of chlormadinone acetate on ventilatory control in patients with chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 133:552-557, 1986.

6. Tatsumi K, Kimura H, Kunitomo F, Kuriyama T, Watanabe S, Honda Y. Sleep arterial oxygen desaturation and chemical control of breathing during wakefulness in COPD. Chest. 90:68-73, 1986.

7. Tojima H, Kunitomo F, Okita S, Yuguchi Y, Tatsumi K, Kimura H, Kuriyama T, Watanabe S, Honda Y. Difference in the effects of acetazolamide and ammonium cloride acidosis on ventilatory responses to CO2 and hypoxia in humans. Jpn. J. Physiol. 36:511-521, 1986.

8. Nishibayashi Y, Kimura H, Maruyama R, Ohyabu Y, Masuyama H, Honda Y. Differences in ventilatory responses to hypoxia and hypercapnia between normal and judo athletes with moderate obesity. Eur. J. Appl. Physiol. 56:144-150, 1987.

9. Okita S, Kimura H, Kunitomo F, Tojima H, Yuguchi Y, Tatsumi K, Kuriyama T, Watanabe S, Honda Y. Effects of chlormadinone acetate, a synthetic progesterone, on hypoxic ventilatory response in men. Jpn. J. Physiol. 37:137-147, 1987.

10. Tatsumi K, Kimura H, Kunitomo F, Kuriyama T, Watanabe S, Honda Y. Effects of chlormadinone acetate on sleep arterial oxygen desaturation in patients with chronic obstructive pulmonary disease. Chest. 91:688-692, 1987.

11. Honda Y, Hashizume I, Kimura H, Severinghaus JW. Bilateral carotid body resection in man enhances hypoxic tachycardia. Jpn. J. Physiol. 38:917-928, 1988.

12. Kimura H, Nishibayashi Y, Hayashi F, Yoshida A, Honda Y. Influence of controlled breathing with diminished tidal volume on hypoxic heart rate response in man. Respiration. 54:103-109, 1988.

13. Kimura H, Tatsumi K, Kunitomo F, Okita S, Tojima H, Kouchiyama S, Masuyama S, Shinozaki T, Mikami M, Watanabe S, Ishikawa I, Honda Y, Kuriyama T. Obese patients with sleep apnea syndrome treated by progesterone. Tohoku J. Exp. Med. 156:151-157, 1988.

14. Kunitomo F, Kimura H, Tatsumi K, Kuriyama T, Watanabe S, Honda Y Sex differences in awake ventilatory drive and abnormal breathing during sleep in eucapnic obesity. Chest. 93:968-976, 1988.

15. Tojima H, Kunitomo F, Kimura H, Tatsumi K, Kuriyama T, Honda Y. Effects of acetazolamide in patients with sleep apnea syndrome. Thorax. 43:113-119, 1988.

16. Fukuda Y, Kobayashi T, Kimura H, Maruyama R. Increased ventilatory response to acute hypoxia with high Hb-O2 affinity by Na-cyanate treatment in the rat. Adv. Exp. Med. Biol. 222:331-339, 1988.

17. Kimura H, Tatsumi K, Kunitomo F, Okita S, Tojima H, Kouchiyama S, Masuyama S, Shinozaki T, Honda Y, Kuriyama T. Progesterone therapy for sleep apnea syndrome evaluated by occlusion pressure responses to exogenous loading. Am. Rev. Respir. Dis. 139:1198-1206, 1989.

18. Kimura H, Mikami M, Kuriyama T, Fukuda Y.　Effect of a synthetic progestin on ventilatory response to hypoxia in anesthetized rats.　J. Appl. Physiol. 67:1754-1758, 1989.

19. Kunitomo F, Kimura H, Tatsumi K, Okita S, Tojima H, Kuriyama T. Honda Y. Abnormal breathing during sleep and chemical control of breathing during wakefulness in patients with sleep apnea syndrome. Am. Rev. Respir. Dis. 139:164-169, 1989.

20. Masuyama S, Kouchiyama S, Shinozaki T, Okita S, Kunitomo F, Tojima H, Kimura H, Kuriyama T, Honda Y. Periodic breathing at high altitude and ventilatory responses to O2 and CO2.　Jpn. J. Physiol. 39:523-535, 1989.

21. Mikami M, Tatsumi K, Kimura H, Honda Y, Kuriyama T. Respiration effect of synthetic progestin in small doses in normal men.　Chest. 96:1073-1075, 1989.

22. Tatsumi K, Kimura H, Kunitomo F, Kuriyama T, Honda Y. Arterial oxygen desaturation during sleep in interstitial pulmonary disease: correlation with chemical control of breathing during wakefulness.　Chest. 95:962-967, 1989.

23. Kimura H, Kubin L, Davies RO, Pack AI. Cholinergic stimulation of the pons depresses respiration in decerebrate cats. J. Appl. Physiol. 69:2280-2289, 1990.

24. Masuyama S, Shinozaki T, Kouchiyama S, Okita S, Kimura H, Honda Y, Kuriyama T. Heart rate depression during sleep apnea depends on hypoxic chemosensitivity: a study at high altitude. Am. Rev. Respir. Dis. 141:39-42, 1990.

25. Kubin L, Kimura H, Davies RO. The medullary projections of afferent bronchopulmonary C-fibers in the cat as shown by antidromic mapping. J. Physiol. - London 435:207-228, 1991.

26. Tanaka M, Kimura H, Kunitomo F, Sakuma T, Kurono T, Hasako K, Uruma T, Kuriyama T. Honda Y. Effect of sustained hypoxia on ventilatory and heart rate responses in carotid body-resected humans. Jpn. J. Appl. Physiol. 22:81-87, 1992.

27. Kubin L, Kimura H, Tojima H, Pack AI, Davies RO. Behavior of VRG neurons during the atonia of REM sleep induced by pontine carbachol in decerebrate cats. Brain Res. 592:91-100, 1992.

28. Tojima H, Kubin L, Kimura H, Davies RO. Spontaneous ventilation and respiratory motor output during carbachol-induced atonia of REM sleep in decerebrate cat.　Sleep. 15:404-414, 1992.

29. Kimura H, Niijima M, Edo H, Honda Y, Kuriyama T. The effect of hypoxic depression on genioglossal muscle activity in healthy subjects and obstructive sleep apnea patients. Sleep. 16:135-136, 1993.

30. Kubin L, Kimura H, Tojima H, Davies RO, Pack AI. Suppression of hypoglossal motoneurons during the carbachol-induced atonia of REM sleep is not caused by fast synaptic inhibition.　Brain Res. 611:300-312, 1993.

31. Kimura H, Niijima M, Edo H, Honda Y, Kuriyama T. Differences in the response of genioglossal muscle activity to sustained hypoxia between healthy subjects and patients with obstructive sleep apnea. Respiration. 61:155-160, 1994.

32. Honda Y, Masuda A, Kobayashi T, Tanaka M, Masuyama S, Kimura H, Kuriyama T.　Individual differences in ventilatory and HR responses to progressive hypoxia following 100 % O2 exposure in humans. Adv. Exp. Med. Biol. 393:283-286, 1995.

33. Honda Y, Tani H, Masuda A, Kobayashi T, Nishino T, Kimura H, Masuyama S, Kuriyama T. Effect of prior O2 breathing on ventilatory response to sustained isocapnic hypoxia in adult humans.　J. Appl. Physiol. 81:1627-1632, 1996.

34. Sakuma T, Tatsumi K, Kimura H, Honda Y, Kuriyama T. Sleep oxygen desaturation in late sequelae of pulmonary tuberculosis.　Intern. Med. 35:534 -539, 1996.

35. Honda Y, Tani H, Masuda A, Kobayashi T, Nishino T, Kimura H, Masuyama S, Kuriyama T. Augmented ventilatory response to sustained normocapnic hypoxia following 100% O2 breathing in humans. Adv. Exp. Med. Biol. 410:371-375, 1996.

36. Okita S, Shinozaki T, Masuyama S, Kimura H, Honda Y, Kuriyama T. Analysis of heart rate profile during obstructive sleep apnea. Jpn. J. Appl. Physiol. 27:235-248, 1997.

37. Honda Y, Kimura H, Tanaka M. Role of carotid body activity responsible for hypoxic ventilatory decline in awake humans.　J. Appl. Physiol. 82:371-371, 1997.

38. Igari H, Tatsumi K, Sugito K, Kasahara Y, Saito M, Tani T, Kimura H, Kuriyama T. Role of EDRF in pulmonary circulation during sustained hypoxia. J. Cardiovasc. Pharmacol. 31:299-305, 1998.

39. Kimura H, Niijima M, Abe Y, Edo H, Sakabe H, Kojima A, Hasako K, Masuyama S, Tatsumi K, Kuriyama T. Compensatory excretion of prostacyclin and thromboxane metabolites in obstructive sleep apnea syndrome. Intern. Med. 37:127-133, 1998.

40. Niijima M, Kimura H, Edo H, Hasako K, Masuyama S, Tatsumi K, Honda Y, Kuriyama T. Control of upper airway function in response to hypoxia in patients with obstructive sleep apnea syndrome. Intern. Med. 37:134-140, 1998.

41. Sugito K, Tatsumi K, Igari H, Kasahara Y, Tani T, Kimura H, Hayashi F, Kuriyama T. Role of carotid body in pressure response of pulmonary circulation in rats. Respir. Physiol. 111:283-293, 1998.

42. Yamamoto T, Kimura H, Okada O, Katoh K, Tanabe N, Yasuda J, Yoshida Y, Kuriyama T. Arterial and mixed venous oxygen desaturation during incremental exercise in patients with chronic pulmonary disease. Intern. Med. 37:280-285, 1998.

43. Kimura H, Suda A, Sakuma T, Tatsumi K, Kawakami Y, Kuriyama T, Institutions participating in the Respiratory Failure Research Group in Japan. Nocturnal oxyhemoglobin desaturation and prognosis in COPD and late sequelae of pulmonary tuberculosis. Intern. Med. 37:354-359, 1998.

44. Edo H, Kimura H, Niijima M, Sakabe H, Shibuya M, Kanamaru A, Homma I, Kuriyama T. Effects of chest wall vibration on breathlessness during hypercapnic ventilatory response. J. Appl. Physiol. 84:1487-1491, 1998.

45. Kimura H, Kasahara Y, Kurosu K, Sugito K, Takiguchi Y, Terai M, Mikata A, Natsume M, Mukaida N, Matsushima K, Kuriyama T. Alleviation of monocrotaline-induced pulmonary hypertension by antibodies to a monocyte chemotactic and activating factor/monocyte chemoattractant protein-1. Lab. Invest. 78:571-581, 1998.

46. Yamada Y, Uchida Y, Tatsumi K, Yamaguchi T, Kimura H, Kitahara H, Kuriyama T. Fluorine-18- fluorodeoxyglucose and carbon-11-methionine evaluation of lymphadenopathy in sarcoidosis. J Nucl Med. 39:1160-1166, 1998.

47. Kimura H, Tanaka M, Nagao K, Niijima M, Masuyama S, Mizoo A, Uruma T, Tatsumi K, Kuriyama T, Masuda A, Kobayashi T, Honda Y. A new aspect of the carotid body function controlling hypoxic ventilatory decline in humans. Appl Human Sci. 17:131-137, 1998.

48. Takiguchi Y, Moriya T, Omori S, Suda A, Miyazawa H, Sugimoto T, Iioka Y, Yasuda J, Kimura H, Nagao K, Kuriyama T. Deterioration of clinical course in patients with advanced primary lung cancer and atelectasis. J. Bronchol. 5:293-297, 1998.

49. Masuda A, Chowdhury MF, Tanaka M, Kobayashi T, Masuyama S, Kimura H, Kuriyama T, Honda Y. Possible presence of hypoxic ventilatory depression while breathing ambient air at sea level in humans. Pathophysiology. 5:149-154, 1998.

50. Masuda A, Kobayashi T, Ohyabu Y, Nishino T, Masuyama S, Kimura H, Kuriyama T, Tani H, Komatsu T, Honda Y. Effect of prior O2 breathing on hypoxic hypercapnic ventilatory responses in humans. Adv Exp Med Biol. 450:1-6, 1998.

51. Niijima M, Kimura H, Edo H, Shinozaki T, Kang J, Masuyama S, Tatsumi K, Kuriyama T. Manifestation of pulmonary hypertension during REM sleep in obstructive sleep apnea syndrome. Am J Respir Crit Care Med. 159:1766-1772, 1999.

52. Hamada H, Terai M, Kimura H, Hirano K, Oana S, Niimi H. Increased expression of mast cell chymase in the lungs of congenital heart disease associated with early pulmonary vascular disease. Am J Respir Crit Care Med. 160:1303-1308, 1999.

53. Uruma T, Kimura H, Kojima A, Hasako K, Masuyama S, Tatsumi K, Kuriyama T. Volume acceleration as an index of respiratory drive during exercise. Clin. Sci. 98:91-101, 2000.

54. Tokuda A, Itakura M, Onai N, Kimura H, Kuriyama T, Matsushima K. Pivotal role of CCR1+-positive leukocytes in bleomycin-induced lung fibrosis in mice. J. Immunol. 164:2745-2751, 2000.

55. Izumizaki M, Iwase M, Kimura H, Yanai K, Watanabe T, Watanabe T, Homma I. Lack of temperature-induced polypnea in histamine H1 receptor-deficient mice. Neurosci let. 284:139-142, 2000.

56. Izumizaki M, Iwase M, Kimura H, Kuriyama T, Homma I. Central histamine contributed to the temperature-induced polypnea in mice. J Appl Physiol. 89:770-776, 2000.

57. Cho K, Ozawa S, Kurihara M, Takeno Y, Kimura H, Kuriyama T. Cardiorespiratory changes in thoracoscopy under local anesthesia. J. Bronchol. 7:215-220, 2000.

58. Moriya T, Takiguchi Y, Tabeta H, Watanabe R, Kimura H, Nagao K, Kuriyama T. Controlling malignant pericardial effusion by intrapericardial carboplatin administration in patients with primary non-small-cell lung cancer. Brit. J. Cancer. 83:858-862, 2000.

59. Itakura M, Tokuda A, Kimura H, Nagai S, Yoneyama H, Onai N, Ishikawa S, Kuriyama T, Matsushima K. Blockade of secondary lymphoid-tissue chemokine (SLC) exacerbates Propionibacterium acnes (P. acnes)-induced acute lung inflammation. J. Immunol. 166:2071-2079, 2001.

60. Abe Y, Tatsumi K, Sugito K, Ikeda Y, Kimura H, Kuriyama T. Effects of inhaled prostacyclin analogue on chronic hypoxic pulmonary hypertension. J. Cardiovasc. Pharmacol. 37:239-251, 2001.

61. Kimura H, Okada O, Tanabe N, Tanaka Y, Terai M, Takiguchi Y, Masuda M, Nakajima N, Inadera H, Matsushima K, Kuriyama T. Plasma MCP-1 and pulmonary vascular resistance in chronic thromboembolic pulmonary hypertension. Am J Respir Crit Care Med. 164:319-324, 2001.

62. Takiguchi Y, Uruma T, Hiroshima K, Motoori K, Watanabe R, Hamaoka T, Okada O, Kimura H, Kuriyama T. Stable pulmonary capillary haemangiomatosis without symptomatic pulmonary hypertension. Thorax. 56:815-817, 2001.

63. Omori S, Takiguchi Y, Suda A, Sugimoto T, Miyazawa H, Takiguchi Y, Tanabe N, Tatsumi K, Kimura H, Pardington PE, Chen F, Chen DJ, Kuriyama T. Suppression of a DNA double-strand break repair gene, Ku70, increases radio- and chemosensitivity in a human lung carcinoma cell line. DNA Repair (Amst). 1:299-310, 2002.

64. Omori S, Takiguchi Y, Hiroshima K, Tanabe N, Tatsumi K, Kimura H, Nagao K, Kuriyama T. Peripheral pulmonary diseases: evaluation with endobronchial US initial experience. Radiology. 224:603-608, 2002.

65. Watanabe A, Kawabata Y, Okada O, Tanabe N, Kimura H, Hatamochi A, Shinkai H, Sakai N, Shimada T, Hiroshima K, Kuriyama T. Ehlers-Danlos syndrome type IV with few extrathoracic findings: a newly recognized point mutation in the COL3A1 gene. Eur Respir J. 19:195-198, 2002.

66. Fukuoka K, Arioka H, Iwamoto Y,Fukumoto H,Kurokawa H, Ishida T, Tomonari A, Suzaki T, Usuda T, Kanzawa F, Kimura H, Saijo N, Nishio K． Mechanism of vinorelbine-induced radiosensiti zation of humansmall cell lung cancer cells． Cencer Chemother Pharmacol. 49:385-390, 2002.

67. Kasahara K, Fukuoka K, Konishi M, Hamada K, Maeda K, Mikasa K, Kimura H. Two cases of endobronchial neurilemmoma and review of the literature in Japan. Intern Med. 42:1215-1218, 2003.

68. Fukuoka K, Nakano Y, Nakajima A, Hontsu S, Kimura H. Endobronchial lesions involved in Mycobacterium avium infection. Respir Med. 97:1261-1264, 2003.

69. Takahashi K, Kita E, Konishi M, Yoshimoto E, Mikasa K, Narita N, Kimura H. Translocation model of Candida albicans in DBA-2/J mice with protein calorie malnutrition mimics hematogenous candidiasis in humans. Microb Pathog. 35:179-187, 2003.

70. Izumizaki M, Tamaki M, Suzuki Y, Iwase M, Shirasawa T, Kimura H, Homma I. The affinity of hemoglobin for oxygen affects ventilatory responses in mutant mice with Presbyterian hemoglobinopathy. Am J Physiol Regul Integr Comp Physiol. 285:R747-753, 2003.

71. Suda A, Takiguchi Y, Omori S, Miyazawa H, Sugimoto T, Kurosu K, Tatsumi K, Tanabe N, Kuriyama T, Hiroshima K, Kimura H. Gene delivery to the lung by means of syngeneic fibroblasts: an experimental model. Exp Lung Res. 29:227-241, 2003.

72. Hida W, Okabe S, Tatsumi K, Kimura H, Akasiba T, Chin K, Ohi M, Nakayama H, Satoh M, Kuriyama T. Nasal continuous positive airway pressure improves quality of life in obesity hypoventilation syndrome. Sleep Breath. 7:3-12, 2003.

73. Hontsu S, Yoneyama H, Ueha S, Terashima Y, Kitabatake M, Nakano A, Ito T, Kimura H, Matsushima K. Visualization of naturally occurring Foxp3+ regulatory T cells in normal and tumor-bearing mice. Int Immunopharmacol. 4:1785-1793, 2004.

74. Miyamoto K, Iwase M, Kimura H, Homma I. Central histamine contributes to the inspiratory off-switch mechanism via H1 receptors in mice. Respir Physiol Neurobiol. 144:25-33, 2004.

75. Itoh T, Nagaya N, Murakami S, Fujii T, Iwase T, Ishibashi-Ueda H, Yutani C, Yamagishi M, Kimura H, Kangawa K. C-type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats. Am J Respir Crit Care Med. 170:1204-1211, 2004.

76. Murakami S, Nagaya N, Itoh T, Fujii T, Iwase T, Hamada K, Kimura H, Kangawa K. C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol. 287:L1172-1177, 2004.

77. Nishiwaki T, Yoneyama H, Eishi Y, Matsuo N, Tatsumi K, Kimura H, Kuriyama T, Matsushima K. Indigenous pulmonary Propionibacterium acnes primes the host in the development of sarcoid-like pulmonary granulomatosis in mice. Am J Pathol. 165:631-639, 2004.

78. Itoh T, Nagaya N, Yoshikawa M, Fukuoka A, Takenaka H, Shimizu Y, Haruta Y, Oya H, Yamagishi M, Hosoda H, Kangawa K, Kimura H. Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 170:879-882, 2004.

79. Yamamoto Y, Tsujimoto M, Konoike Y, Nakamine H, Morii T, Kimura H. Richter's syndrome presenting as a nasal lymphoma. Leuk Lymphoma. 45:1919-1923, 2004.

80. Ito T, Ishikawa S, Sato T, Akadegawa K, Yurino H, Kitabatake M, Hontsu S, Ezaki T, Kimura H, Matsushima K. Defective B1 cell homing to the peritoneal cavity and preferential recruitment of B1 cells in the target organs in a murine model for systemic lupus erythematosus. J Immunol. 172:3628-3634, 2004.

81. Suzuki T, Nakano H, Maekawa J, Okamoto Y, Ohnishi Y, Yamauchi M, Kimura H. Obstructive sleep apnea and carotid-artery intima-media thickness. Sleep. 27:129-133, 2004.

82. Kasahara K, Maeda K, Mikasa K, Uno K, Takahashi K, Konishi M, Yoshimoto E, Murakawa K, Kita E, Kimura H. Longterm azithromycin therapy for three patients with chronic lower respiratory tract infections. J Infect Chemother. 10:42-45, 2004.

83. Itoh T, Nagaya N, Fujii T, Iwase T, Nakanishi N, Hamada K, Kangawa K, Kimura H. A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats. Am J Respir Crit Care Med. 169:34-38, 2004.

84. Yamamoto Y, Morii T, Kimura H． Paralytic ileus occurring during treatment with all-trans retinoic acid for acute promyelocytic leukemia． Int J Hematol． 79:198-199, 2004．

85. Murakami S, Nagaya N, Itoh T, Fujii T, Iwase T, Hamada K, Kimura H, Kangawa K. C-type natriuretic peptide attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung CellMol Physiol. 287:1172-1177, 2004.

86. Suzaki Y, Hamada K, Sho M, Ito T, Miyamoto K, Akashi S, Kashizuka H, Ikeda N, Nakajima Y, Iwase M, Homma I, Kobzik L, Kimura H. A potent antiangiogenic factor, endostatin prevents the development of asthma in a murine model. J Allergy Clin Immunol. 116:1220-1227, 2005.

87. Murakami S, Nagaya N, Itoh T, Iwase T, Fujisato T, Nishioka K, Hamada K, Kangawa K, Kimura H. Adrenomedullin regenerates alveoli and vasculature in elastase-induced pulmonary emphysema in mice. Am J Respir Crit Care Med. 172:581-589, 2005.

88. Yamauchi M, Nakano H, Maekawa J, Okamoto Y, Ohnishi Y, Suzuki T, Kimura H. Oxidative stress in obstructive sleep apnea. Chest. 127:1674-1679, 2005.

89. Kasahara K, Kita E, Maeda K, Uno K, Konishi M, Yoshimoto E, Murakawa K, Mikasa K, Kimura H. Macrolide resistance of Streptococcus pneumoniae isolated during long-term macrolide therapy: difference between erythromycin and clarithromycin. J Infect Chemother. 11:112-114, 2005.

90. Kasahara K, Fukuoka A, Murakawa K, Okamura H, Mikasa K, Narita N, Kimura H. Tuberculous peritonitis developing during chemotherapy for pulmonary and intestinal tuberculosis: a case report. Respirology. 10:257-260, 2005.

91. Kasahara K, Maeda K, Mikasa K, Uno K, Takahashi K, Konishi M, Yoshimoto E, Murakawa K, Kita E, Kimura H. Clonal dissemination of macrolide-resistant and penicillin-susceptible serotype 3 and penicillin-resistant Taiwan 19F-14 and 23F-15 Streptococcus pneumoniae isolates in Japan: a pilot surveillance study. J Clin Microbiol. 43:1640-1645, 2005.

92. Yoneda K, Morii T, Nieda M, Tsukaguchi N, Amano I, Tanaka H, Yagi H, Narita N, Kimura H. The peripheral blood Valpha24+ NKT cell numbers decrease in patients with haematopoietic malignancy. Leuk Res. 29:147-152, 2005.

93. Fujita Y, Kasahara K, Uno K, Konishi M, Maeda K, Yoshimoto E, Murakawa K, Mikasa K, Amano I, Morii T, Kimura H． Amphotericin B-induced nephrogenic diabets insipidus in a case of cryptococcemia． Intern Med． 44:458-461, 2005．

94. Ito T, Hamada K, Suzaki Y, Matsui N, Kita E, Kimura H． Subcutaneous Vaccination of Mycobacterium bovis Bacillus Calmette-Guerin Attenuates Allergic Inflammation in a Murine Model of Asthma.　 Allergology International. 54:601-609, 2005.

95. Yamauchi M, Nakano H, Maekawa J, Okamoto Y, Ohnishi Y, Suzuki T, Kimura H. Oxidative stress in obstructive sleep apnea. Chest. 127:1674-1679, 2005.

96. Yamauchi M, Tamaki S, Tomoda K, Yoshikawa M, Fukuoka A, Makinodan K, Koyama N, Suzuki T, Kimura H. Evidence for activation of nuclear factor kappaB in obstructive sleep apnea. Sleep Breath. 10:189-193, 2006.

97. Murakami S, Kimura H, Kangawa K, Nagaya N. Physiological significance and therapeutic potential of adrenomedullin in pulmonary hypertension. Cardiovasc Hematol Disord Drug Targets. 6:125-132, 2006.

98. Miyamoto K, Iwase M, Nyui M, Arata S, Sakai Y, Gabazza EC, Kimura H, Homma I. Histamine type 1 receptor deficiency reduces airway inflammation in a murine asthma model. Int Arch Allergy Immunol. 140:215-222, 2006.

99. Itoh T, Nagaya N, Ishibashi-Ueda H, Kyotani S, Oya H, Sakamaki F, Kimura H, Nakanishi N. Increased plasma monocyte chemoattractant protein-1 level in idiopathic pulmonary arterial hypertension. Respirology. 11:158-163, 2006.

100. Murakami S, Nagaya N, Itoh T, Kataoka M, Iwase T, Horio T, Miyahara Y, Sakai Y, Kangawa K, Kimura H. Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol. 290:L59-65, 2006.

101. Kai Y, Yoneyama H, Koyama J, Hamada K, Kimura H, Matsushima K. Treatment with chondroitinase ABC alleviates bleomycin-induced pulmonary fibrosis. Med Mol Morphol. 40:128-140, 2007.

102. Tomoda K, Yoshikawa M, Itoh T, Tamaki S, Fukuoka A, Komeda K, Kimura H. Elevated circulating plasma adiponectin in underweight patients with COPD. Chest. 132:135-140, 2007.

103. Itoh T, Obata H, Murakami S, Hamada K, Kangawa K, Kimura H, Nagaya N. Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol. 293:L446-452, 2007.

104. Takeda M, Arao T, Yokote H, Komatsu T, Yanagihara K, Sasaki H, Yamada Y, Tamura T, Fukuoka K, Kimura H, Saijo N, Nishio K. AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor. Clin Cancer Res. 15;13:3051-3057, 2007.

105. Hamada K, Suzaki Y, Leme A, Ito T, Miyamoto K, Kobzik L, Kimura H. Exposure of pregnant mice to an air pollutant aerosol increases asthma susceptibility in offspring. J Toxicol Environ Health A. 70:688-695, 2007.

106. Suzaki Y, Hamada K, Nomi T, Ito T, Sho M, Kai Y, Nakajima Y, Kimura H. A small-molecule compound targeting CCR5 and CXCR3 prevents the development of asthma. Eur. Respir. J. 31:783-789, 2008.

107. Makinodan K, Yoshikawa M, Fukuoka A, Tamaki S, Koyama N, Yamauchi M, Tomoda K, Hamada K, Kimura H. Effect of Serum Leptin Levels on Hypercapnic Ventilatory Response in Obstructive Sleep Apnea. Respiration. 75:257-364, 2008.

108. Yamauchi M, Dostal J, Kimura H, Strohl KP. Effects of buspirone on posthypoxic ventilatory behavior in the C57BL/6J and A/J mouse strains. J. Appl. Physiol. 105:518-526, 2008.

109. Makinodan K, Itoh T, Tomoda K, Tamaki S, Koyama N, Yoshikawa M, Hamada K, Kimura H. Acute pulmonary thromboembolism associated with interstitial pneumonia. Intern. Med. 47:647-650, 2008.

110. Kitamura K, Asada H, Iida H, Fukumoto T, Kobayashi N, Niizeki H, Morii T, Kimura H, Miyagawa S. Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogeneic stem cell transplantation. J. Am. Acad. Dermatol. 58:802-809, 2008.

111. Yamauchi M, Kimura H． Oxidative stress in obstructive sleep apnea: putative pathways to the cardiovascular complications． Antioxid Redox Signal. 10:755-768, 2008.

112. Tamaki S, Yamauchi M, Fukuoka A, Makinodan K, Koyama N, Tomoda K, Yoshikawa M, Kimura H. Nocturnal hypoxic stress activates invasive ability of monocytes in patients with obstructive sleep apnoea syndrome. Respirology. 14:689-694, 2009.

113. Tamaki S, Yamauchi M, Fukuoka A, Makinodan K, Koyama N, Tomoda K, Yoshikawa M, Kimura H. Production of inflammatory mediators by monocytes in patients with obstructive sleep apnea syndrome. Intern. Med. 48:1255-1262, 2009.

114. Kumamoto M, Nishiwaki T, Matsuo N, Kimura H, Matsushima K.　Minimally-cultured Bone Marrow mesenchymal stem cells ameliorate fibrotic lung injury. Eur. Respir. J. 34:740-748, 2009.

115. Yamamoto Y, Konoike Y, Nakamine H, Nakamura S, Morii T, Kimura H. Multiple myeloma with a variant Burkitt-type translocation, t(2;8)(p12;q24), associated with hyperammonemia. Intern Med. 48:1239-1242, 2009.

116．Takegami M, Hayashino Y, Chin K, Sokejima S, Kadotani H, Akashiba T, Kimura H, Ohi M, Fukuhara S. Simple Four-Variable Screening Tool for Identification of Patients with Sleep-Disordered Breathing． Sleep. 32:939-948, 2009．

117. Yamauchi M, Kimura H, Strohl KP. Mouse models of apnea: strain differences in apnea expression and its pharmacologic and genetic modification. Adv Exp Med Biol. 669:303-307, 2010.

118. Kimura H, Toga H, Yamaya M, Mishima M, Nukiwa T, Kudo S. Current Situations and Issues in Respiratory Medicine in Japan. Japan Medical Association Journal. 53:178-184, 2010.

119. Tasaki M, Shimada K, Kimura H, Tsujikawa K, Konishi N. ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer. Br J Cancer. 104:700-706, 2011.

120. Yamauchi M, Tamaki S, Yoshikawa M, Ohnishi Y, Nakano H, Jacono FJ, Loparo KA, Strohl KP, Kimura H. Differences in Breathing Patterning during Wakefulness in Patients with Mixed-Apnea Dominant vs. Obstructive-Dominant Sleep Apnea. Chest. 140:54-61, 2011.

121. Yoshikawa M, Koyama N, Hontsu S, Yamamoto Y, Mikasa K, Kimura H. Lessons from eight cases of adult pulmonary toxocariasis - abridged republication. Respirology. 16:1014-1015, 2011.

122. Tomoda K, Kubo K, Asahara T, Andoh A, Nomoto K, Nishii Y, Yamamoto Y, Yoshikawa M, Kimura H. Cigarette smoke decreases organic acids levels and population of bifidobacterium in the caecum of rats. J Toxicol Sci. 36:261-266, 2011.

123. Maruyama H, Toyoda-Hirana Y, Nakamura T, Enomoto Y, Hamada K, Kimura H. An autopsy case of portopulmonary hypertension associated with alcoholic liver cirrhosis. J Nara Med Assoc. 62:81-87, 2011.

124．Ota H, Tamaki S, Itaya-Horinaka A, Yamauchi A, Sakuramoto-Tsuchida S, Morioka T, Takasawa S, Kimura H． Attenuation of glucose-induced insulin secretion by intermittent hypoxia viadown-regulaion of CD38． Life Sciences. 90:206-211, 2012.

125．Tomoda K, Kubo K, Nisii Y, Yamamoto Y, Yoshikawa M, Kimura H．Changes of ghrelin and leptin levels in plasma by cigarette smoke in rats． J Toxicol Sci. 39:131-138, 2012.

126. Okada H, Hontsu S, Miura S, Asakawa I, Tamamoto T, Katayama E, Iwasaki S, Kimura H, Kichikawa K, Hasegawa M. Changes of tumor size and tumor contrast enhancement during radiothrapy for non-small-cell lung cancer may be suggestive of treatment response． J Radia Res. 53:326-332, 2012.

127. Hasegawa K, Kimura H, Bando YK, Takahashi Y, Wada H, Fujita M. Tobacco, Cardiopulmonary Vascular Disease, and Aging. Anti-aging Med. 9:51-60, 2012.

128. Tomoda K, Kubo K, Asahara T, Nomoto K, Nishii Y, Yamamoto Y, Yoshikawa M, Kimura H． Suppressed anti-oxidant capacity due to a cellulose-free diet declines further by cigarette smoke in mice． J Toxicol Sci. 37:575-585, 2012.

129. Morita K, Nakamine H, Inoue R, Takano M, Takeda M, Enomoto Y, Kasai T, Nonomura A, Tanaka H, Amano I, Morii T, Kimura H. Autopsy case of primary myelofibrosis in which myeloid sarcoma was the initial manifestation of tumor progression. Pathol Int. 62(6):433-7, 2012.

130. Koyama N, Matsumoto M, Tamaki S, Yoshikawa M, Fujimura Y, Kimura H． Reduced larger VWF multimers at dawn in OSA plasmas reflect severity of apneic episodes． Eur Respir J. 40:657-664, 2012.

131. Miki K, Maekura R, Nagaya N, Nakazato M, Kimura H, Murakami S, Ohnishi S, Hiraga T, Miki M, Kitada S, Yoshimura K, Tateishi Y, Arimura Y, Matsumoto N, Yoshikawa M, Yamahara K, Kangawa K． Ghrelin treatment of cachectic patients with chronic obstructive pulmonary disease: a multicenter, randomized, double-blind, placebo-controlled trial． PLoS One. 7:e35708, 2012.

132. Tomita K, Sano H, Iwanaga T, Ishihara K, Ichinose M, Kawase I, Kimura H, Hirata K, Fujimura M, Mishima M, Tohda Y. Association between episodes of upper respiratory infection and exacerbation in adult patients with asthma.　 J Asthma. 49:253-259, 2012.

133. Tomoda K, Kimura H, Osaki S. Distribution of collagen fiber orientation in the human lung. Anat Rec (Hoboken). 296(5):846-50, 2013.

134. Yamauchi M, Jacono FJ, Fujita Y, Yoshikawa M, Ohnishi Y, Nakano H, Campanaro CK, Loparo KA, Strohl KP, Kimura H. Breathing irregularity during wakefulness associated with CPAP acceptance in sleep apnea. Sleep Breath. 17(2):845-52, 2013.

135. NakamuraA, Nagaya N, Obata H, Sakai K, Sakai Y, Yoshikawa M, Hamada K, Matsumoto K, Kimura H. Oral administration of a novel long-acting prostacyclin agonist with thromboxane synthase inhibitory activity for pulmonary arterial hypertension．Circ J. 77(8):2127-33, 2013.

136. Kyotani Y, Ota H, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Zhao J, Ozawa K, Nagayama K, Ito S, Takasawa S, Kimura H, Uno M, Yoshizumi M．Intermittent hypoxia induces the proliferation of rat vascular smooth muscle cell with the increases in epidermal growth factor family and erbB2 receptor．Exp Cell Res. 319(19):3042-3050, 2013.

137. Ota H, Itaya-Hironaka S, Yamauchi A, Sakuramoto-Tsuchida S, Miyaoka T, Fujimura T, Tsujinaka H, Yoshimoto K, Nakagawara K, Tamaki S, Takasawa S, Kimura H．Pancreatic β cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene．Life Sci. 93(18-19):664-672, 2013.

138. Uno K, Kasahara K, Kutsuna S, Katanami Y, Yamamoto Y, Maeda K, Konishi M, Ogawa T, Yoneda T, Yoshida K, Kimura H, Mikasa K. Infective endocarditis and meningitis due to Scedosporium prolificans in a renal transplant recipient. J Infact Chemother. 20(2):131-133, 2014.

139. Yamamoto Y, Yoshikawa M, Tomoda K, Fujita Y, Yamauchi M, Fukuoka A　Tamaki S, Koyama N, Kimura H. Distribution of bone mineral content is associated with body weight and exercise capacity in patients with COPD. Respiration. 87(2):158-164, 2014.

140. Yamauchi M, Jacono FJ, Fujita Y, Kumamoto M, Yoshikawa M, Campanaro CK, Loparo KA, Strohl KP, Kimura H. Effects of environment light during sleep on autonomic functions of heart rate and breathing. Sleep And Breathing.18:829-835 2014, in Press

141. Yoshikawa M, Yamauchi M, Fujita Y, Koyama N, Fukuoka A, Tamaki S, Yamamoto Y, Tomoda K, Kimura H. The Impact of Obstructive Sleep Apnea and Nasal CPAP on Circulating Adiponectin Levels. Lung. 192(2):289-295, 2014.

142. Tomoda K, Kubo K, Hino K, Kondoh Y, Nishi Y, Koyama N, Yamamoto Y, Yoshikawa M, Kimura H. Branched　-chain amino acid- rich diet improves skeletal muscle wasting caused by cigarette smoke in rats. J Toxicol Sci. 39(2):331-337, 2014.

143. Tanabe N, Taniguchi H, Tsujino I, Sakamaki F, Emoto N, Kimura H, Miyaji K, Takamura K, Hayashi S, Hanaoka M, Tatsumi K. Current trends in the management of pulmonary hypertension associated with respiratory disease in institutions approved by the Japanese Respiratory Society. Respir Invest. 52:167-172, 2014.

144. Morioka T, Sakabe M, Ioka T, Iguchi T, Mizuta K, Hattammaru M, Sakai C, Itoh M, Sato GE, Hashimoto A, Fujita M, Okumura K, Araki M, Xin M, Pedersen RA, Utset MF, Kimura H, Nakagawa O：An important role of endothelial hairy-related transcription factors in mouse vascular development. Genesis. 52(11)：897-906, 2014.

145. Yoshikawa M, Fujita Y, Yamamoto Y, Yamauchi M, Tomoda K, Koyama N, Kimura H. The Mini Nutritional Assessment Short-form predicts exacerbation frequency in patients with chronic obstructive pulmonary disease. Respirology. 19:1198-1203, 2014.

146. Miura S, Ohno Y, Kimura H, Kichikawa K. Quantitative lung perfused blood volume imaging on dual-energy CT: capability for quantitative assessment of disease severity in patients with acute pulmonary thromboembolism. Acta Radiol. 56:284-293, 2015.

147. Tanabe N, TaniguchiH, Tsujino I, Sakamaki F, Emoto N, Kimura H, Takamura K, Hanaoka M, Nishimura M, TatsumiK, the JRS Lung Disease PH Study Group：Multi-institutional retrospective cohort study of patients with severe pulmonary hypertension associated with respiratory diseases. Respirology. 20(5):805-812, 2015.

148. Matsumoto N, Miki K, Tsubouchi H, Sakamoto A, Arimura Y, Yanagi S, Iiboshi H, Yoshida M, Souma R, Ishimoto H, Yamamoto Y, Yatera K, Yoshikawa M, Sagara H, Iwanaga T, Mukae H, Maekura R, Kimura H, Nakazato M, Kangawa K：Ghrelin Administration for Chronic Respiratory Failure: A Randomized Dose-Comparison Trial. Lung. 193:239-247, 2015.

149. Tomoda K, Kubo K, Dairiki K, Yamaji T, Yamamoto Y, Nishii Y, Nakamura A, Yoshikawa M, Hamada K, Kimura H. Whey peptide-based enteral diet attenuate elastase-induced emphysema with increase in short chain fatty acids in mice. BMC pulm Med. 15:64 DOI 10.1186/s12890-015-0059-2, 2015.

150. Katayama K, Tomoda K, Ohya T, Asada H, Ohbayashi C, Kimura H. Ground-glass opacities and a solitary nodule on chest in intravascular large B-cell lymphoma. Respirology Case Reports. 3:108-111, 2015.

151. Kumamoto M, Tomoda K, Furuya Y, Iwasa N, Ueno S, Yoshikawa M, Kimura H. Hypertrophic pachymeningitis as a delayed complication of granulomatosis with polyangiitis. Intern Med. 2015, in press

152. Yamauchi M, Fujita Y, Kumamoto M, Yoshikawa M, Ohnishi Y, Nakano H, Strohl KP, Kimura H. Nonrapid Eye Movement-Predominant Obstructive Sleep Apnea: Detection and Mechanism. J Clin Sleep Med. 11:987-993, 2015.

153. Iwai K, Tomoda K, Nakai T, Kimura H. A Hypopharyngeal Lipoma Resulting in Obstructive Sleep Apnea. Intern Med. 54(21):2789-2790, 2015.

154. Kai Y, Tomoda K, Yoneyama H, Yoshikawa M, Kimura H. RNA interference targeting carbohydrate sulfotransferase 3 diminishes macrophage accumulation, inhibits MMP-9 expression and promotes lung recovery in murine pulmonary emphysema. Respir Res. 16(1):146, 2015.

155. Ota M, Mochizuki S, Shimoda M, Abe H, Miyamae Y, Ishii K, Kimura H, Okada Y. ADAM23 is downregulated in side population and suppresses lung metastasis of lung carcinoma cells. Cancer Sci. 107:433-443, 2016.

156. Kumamoto M, Tomoda K, Furuya Y, Iwasa N, Ueno S, Yoshikawa M, Kimura H. Hypertrophic pachymeningitis as a delayed complication of granulomatosis with polyangiitis. Intern Med. 55:413-417, 2016.

157. Koguchi N, Okada A, Choh S, Katayama K, Takenaka H, Tomoda K, Kimura H. Concomitant Systemic Sclerosis and Sarcoidosis with Combined Pulmonary Fibrosis and Emphysema. Intern Med. 55:1331-1335, 2016.

158. Fukuoka A, Ueda M, Ariyama Y, Iwai K, Kai Y, Kunimatsu M, Yoshikawa M, Uyama H, Tomoda K, Kimura H. Effect of laughter yoga on pulmonary rehabilitation in patients with chronic obstructive pulmonary disease. J Nara Med Assoc. 67:11-20, 2016.

159. Koyama N, Tomoda K, Matsuda M, Fujita Y, Yamamoto Y, Hontsu S, Tasaki M, Yoshikawa M, Kimura H. Acute Bilateral Renal and Splenic Infarctions Occurring during Chemotherapy for Lung Cancer. Intern Med. 55:3635-3639, 2016.

160. Fujita Y, Yamauchi M, Uyama H, Kumamoto M, Koyama N, Yoshikawa M, Strohl KP, Kimura H. Variability of breathing during wakefulness while using CPAP predicts adherence. Respirology. 22:386-393, 2017.

161. Takeyama M, Nogami K, Matsumoto T, Taguchi M, Yada K, Okahashi N, Amano I, Kimura H, Shima M. Possible assessment of coagulation function and haemostasis therapy using comprehensive coagulation assays in a patient with acquired haemophilia A. Haemophilia. 23:e46-e50, 2017.

162. Kai Y, Tomoda K, Yoneyama H, Kitabatake M, Nakamura A, Ito T, Yoshikawa M, Kimura H. Silencing of carbohydrate sulfotransferase 15 hinders murine pulmonary fibrosis development. Molecular Therapy - Nucleic Acids. 6:163-172, 2017.

163. Yoshikawa M, Yamamoto Y, Tomoda K, Fujita Y, Yamauchi M, Osa T, Uyama H, Okamoto N, Kurumatani N, Kimura H. Prevalence of chronic obstructive pulmonary disease in independent community-dwelling elderly: The Fujiwara-kyo Study. Geriatr Gerontol Int. 17:2421-2426, 2017.

164. Terasaki Y, Ikushima S, Matsui S, Hebisawa A, Ichimura Y, Izumi S, Ujita M, Arita M, Tomii K, Komase Y, Owan I, Kawamura T, Matsuzawa Y, Murakami M, Ishimoto H, Kimura H, Bando M, Nishimoto N, Kawabata Y, Fukuda Y, Ogura T. Comparison of clinical and pathological features of lung lesions of systemic IgG4-related disease and idiopathic multicentric Castleman's disease. Histopathology. 70:1114-1124, 2017.

165. Tamura Y, Kumamaru H, Satoh T, Miyata H, Ogawa A, Tanabe N, Hatano M, Yao A, Abe K, Tsujino I, Fukuda K, Kimura H, Kuwana M, Matsubara H, Tatsumi K; Japan PH Registry (JAPHR) Network.　 Effectiveness and Outcome of Pulmonary Arterial Hypertension-Specific Therapy in Japanese Patients with Pulmonary Arterial Hypertension. Circ J. 82(1):275-282,2017.

166. Uchiyama T, Ota H, Itaya-Hironaka A, Shobatake R, Yamauchi A, Sakuramoto-Tsuchida S, Makino M, Kimura H, Takeda M, Ohbayashi C, Takasawa S. Up-regulation of selenoprotein P and HIP/PAP mRNAs in hepatocytes by intermittent hypoxia via down-regulation of miR-203. Biochem Biophys Rep. 11:130-137, 2017.

167. Smid DE, Franssen FME, Kimura H, Yoshikawa M, et al. Redefining cut-points for high symptom burden of the Global Initiative for Chronic Obstructive Lung Disease classification in 18,577 patients with chronic obstructive pulmonary disease. J Am Med Dir Assoc. 18: 1097.e11-1097.e24, 2017.

168. Uyama H, Yamauchi M, Fujita Y, Yoshikawa M, Ohnishi Y, Kimura H. The effect of arousal accompanying an apneic event on blood pressure and sympathetic nerve activity in severe obstructive sleep apnea. Sleep Breathing. 22:149-155, 2018.

169. Fujita Y, Yamauchi M, Uyama H, Oda H, Igaki M, Yoshikawa M, Kimura H. The effects of heated humidification to nasopharynx on nasal resistance and breathing pattern. PLoS One. 2019 Feb 6;14(2):e0210957. doi: 10.1371/journal.pone.0210957.eCollection.

170. Kimura H, Ota H, Kimura Y, Takasawa S. Effects of Intermittent Hypoxia on Pulmonary Vascular and Systemic Diseases. Int J Environ Res Public Health. 2019 Aug 26;16(17). pii: E3101. doi: 10.3390/ijerph16173101.

171. Ota H, Fujita Y, Yamauchi M, Muro S, Kimura H, Takasawa S. Relationship Between Intermittent Hypoxia and Type 2 Diabetes in Sleep Apnea Syndrome. Int J Mol Sci. 2019 Sep 25;20(19). pii: E4756. doi: 10.3390/ijms20194756.

獲得研究費

【文部科学省（日本学術振興会）科学研究費】

1. 交通事故における睡眠時無呼吸症候群の関与に関する研究（分担）
1990年度-1990年度
一般研究 (C)

2. ヒマラヤ地域の高所極低酸素下における人体の順応機構に関する総合的研究 -京都大学・千葉大学合同プロジェクト-（分担）
1990年度-1992年度
国際学術研究

3. 低圧低酸素環境下での呼吸循環応答に関する研究（分担）
1991年度-1991年度
一般研究 (C)

4. 人工的低圧低酵素環境下での呼吸循環神経応答に関する研究（分担）
1993年度-1993年度
一般研究 (C)

5. チベット・ネパ-ル高所山岳地域住民における医学衛生疫学的調査研究（分担）
1993年度-1995年度
国際学術研究

6. 睡眠時呼吸異常の病態解明および治療に関する臨床的・基礎的研究（代表）
1993年度-1993年度
一般研究 (C)

7. 高齢者の高所滞在を安全にするための医学的ガイドライン作りに関する研究（分担）
1995年度-1996年度
一般研究 (C)・基盤研究 (C)

8. 実験的REM睡眠モデルを用いた、REM睡眠時の舌下神経活動抑制メカニズムの研究（代表）
1995年度-1996年度
一般研究 (C)・基盤研究 (C)

9. MRSによる慢性呼吸器疾患患者における運動負荷中の筋肉代謝解析法開発に関する研究（分担）
1996年度-1996年度
萌芽的研究

10. トランスジェニックマウスを用いた、放射線による急性肺傷害モデルの研究（分担）
1996年度-1996年度
基盤研究 (C)

11. 肺胞マクロファ-ジを遺伝子担体とした肺疾患の遺伝子治療の可能性の検討（分担）
1997年度-1998年度
基盤研究 (C)

12. 腫瘍間質をターゲットとした癌の遺伝子治療の基礎的検討（分担）
1999年度-2000年度
基盤研究 (C)

13. 難治性肺高血圧症の発症機序におけるケモカイン、ケモカイン受容体の関与と役割（代表）
2000年度-2001年度
基盤研究 (C)

14. 睡眠時無呼吸症候群における低酸素・再灌流ストレスと動脈硬化促進因子に関する研究（代表）
2003年度-2004年度
基盤研究 (C)

15. 肺気腫病態解明への新たなるアプローチ: コラーゲン線維配列の定量的測定法を用いて（分担）
2004年度-2005年度
萌芽研究

16. 大気汚染粉塵が気管支喘息発症要因として次世代におよぼす影響についての研究（分担）
2004年度-2005年度
基盤研究 (C)

17. 肺高血圧ラットモデルにおけるグレリンの抗炎症作用に関する検討（代表）
2005年度-2006年度
萌芽研究

18. ヒト肺の力学強度マップ作製の試み-細葉中心型肺気腫の上肺野からの発症機序の解明（分担）
2006年度-2007年度
基盤研究 (C)

19. 妊娠中の大気汚染曝露は次世代の気管支喘息発症を増加させる（分担）
2007年度-2008年度
基盤研究 (C)

20. 睡眠時無呼吸による低酸素ストレスは全身性炎症を惹起し動脈硬化を促進させる（代表）
2007年度-2009年度
基盤研究 (B)

21. 力学的呼吸負荷に対するヒト肺構造維持のメカニズム:コラーゲン線維三次元配列の解析（分担）
2008年度-2010年度
基盤研究 (C)

22. 慢性閉塞性肺疾患の全身性炎症における肺-消化管ネットワークの意義（分担）
2008年度-2010年度
基盤研究 (C)

23. 妊娠中の大気汚染曝露による喘息発作要因の母子間伝達とその制御機構の解明（分担）
2009年度-2011年度
基盤研究 (C)

24. 肺胞壁断裂の機序解明 への新たなるアプロー チ ?加齢による肺の力学 機能低下を探る?（分担）
2011年度-2013年度
基盤研究 (C)

25. 呼吸不全、肥満低換気症候群における急性増悪は低酸素化学感受性の低下が関与する（代表）
2011年度-2014年度
基盤研究 (C)

26. 消化管免疫による関節リウマチ治療へのアプローチ（分担）
2012年度
挑戦的萌芽研究

27. 慢性閉塞性肺疾患・表現型規定因子の探求―日米比較研究からの発信（分担）
2012年度-2014年度
基盤研究 (C)

28. 慢性閉塞性肺疾患に対する新規栄養療法の開発:進行抑制から発症予防までをめざして（分担）
2012年度-2015年度
基盤研究 (C)

29. 地域在住高齢者のQOLと生活機能の低下要因に関する大規模コホート研究（分担）
2012年度-2015年度
基盤研究 (A)

30. OSASの多様性に対応した個別化治療の構築-薬物療法の可能性の探索-（分担）
2013年度-2015年度
基盤研究 (C)

31. 肺の気腫化と線維化はなぜ均等に起こらないのか？：力学的異方性からのアプローチ（分担）
2015年度-2017年度
基盤研究(Ｃ)

32. 呼吸波形解析を活用した新たなCOPD治療戦略の構築 ―呼吸の安定化を目指して―（分担）
2016年度-2018年度
基盤研究（C）

33. 慢性閉塞性肺疾患の新規治療戦略：全身性炎症の抑制をめざして（分担）
2016年度-2018年度
基盤研究（C）

34. 慢性閉塞性肺疾患における肺-消化管ネットワーク：Autophagyからの機序解明（代表）
2016年度-2018年度
基盤研究（C）

35. 多系統萎縮症に合併する睡眠呼吸障害の多様性―呼吸管理から生命予後改善をめざす―（分担）
2017年度-2020年度
基盤研究（C）

【厚生労働省厚生科学研究費】

1. 厚生労働科学研究費補助金 難治性疾患克服研究事業
「呼吸不全に関する調査研究」(分担)
2001年度

2. 厚生労働科学研究費補助金 長寿科学総合研究事業
「高齢者慢性閉塞性肺疾患の遺伝的病因と病態解明ならびに新治療戦略の開発」(分担)
2001年度-2002年度

3. 厚生労働科学研究費補助金 難治性疾患克服研究事業
「呼吸不全に関する調査研究」(分担)
2002年度-2004年度

4. 厚生労働科学研究費補助金 循環器病研究委託事業
「Obstructive sleep apneaと循環器病の関連に関する研究」(分担)
2005年度-2006年度

5. 厚生労働科学研究費補助金 難治性疾患克服研究事業
「呼吸不全に関する調査研究」(分担)
2005年度-2007年度

6. 厚生労働科学研究費補助金 難治性疾患克服研究事業
「呼吸不全に関する調査研究」(分担)
2008年度-2010年度

7. 厚生労働科学研究費補助金 医療技術実用化総合研究事業
「慢性呼吸不全に対するグレリンの臨床応用」(分担)
2008年度-2012年度　

8. 厚生労働科学研究費補助金 循環器疾患・糖尿病等生活習慣病総合研究事業
「肥満残存高血圧合併睡眠時無呼吸患者に対する防風通聖散及び大柴胡湯の治療効果の比較と病態生理の解明」(分担)
2010年度-2012年度　

9. 厚生労働省科学研究費補助金 循環器疾患・糖尿病生活習慣病対策総合研究事業
「睡眠呼吸障害による生活習慣病に関する医療情報提供とその効果の評価」(分担)
2010年度-2012年度　

10. 厚生労働科学研究費補助金 難治性疾患克服研究事業
「呼吸不全に関する調査研究」(分担)
2011年度-2013年度

11. 厚生労働科学研究費補助金 厚生労働科学特別研究事業
「呼吸器機能障害の身体障害認定に関する研究」(代表)
2013年度　

12. 厚生労働科学研究費補助金 難治性疾患克服研究事業
「呼吸不全に関する調査研究」(分担)
2014年度-2016年度

13. 厚生労働科学研究費補助金 難治性疾患克服研究事業
「難治性呼吸器疾患・肺高血圧症に関する調査研究」(分担)
2017年度-2019年度